Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 1/20 | 0.94 |
| ▸ | HTT | P42858 | 1/20 | 0.76 |
| ▸ | DNMT1 | P26358 | 4/20 | 0.59 |
| ▸ | DNMT3A | Q9Y6K1 | 3/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | ACHE | P22303 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | DNMT3L | Q9UJW3 | 1/20 | 0.59 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.58 |
| ▸ | FADS1 | O60427 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | GAK | O14976 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1387165 | 0.97 | ERBB2 (1.00) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| Hydrochloric Acid SCHEMBL8812168 | 0.95 | ERBB2 (0.97) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL31197383 | 0.88 | HTT (0.97) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL15923145 | 0.88 | HTT (0.97) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL170830 | 0.84 | ERBB2 (0.73) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL30420824 | 0.84 | ERBB2 (0.73) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL8933763 | 0.84 | ERBB2 (0.77) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL15607580 | 0.83 | ERBB2 (0.73) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL31197391 | 0.83 | HTT (0.69) | ERBB2HTTDNMT1DNMT3AHDAC3 | |
| SCHEMBL15923241 | 0.83 | HTT (0.69) | ERBB2HTTDNMT1DNMT3AHDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2011016952-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | ERBB2 305/4885HTT 832/4885DNMT1 191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.