Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.94 |
| ▸ | TEK | Q02763 | 1/20 | 0.94 |
| ▸ | NPC1 | O15118 | 4/20 | 0.76 |
| ▸ | RAB9A | P51151 | 4/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.76 |
| ▸ | HTT | P42858 | 2/20 | 0.76 |
| ▸ | EGFR | P00533 | 8/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.73 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.73 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.73 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.73 |
| ▸ | LTK | P29376 | 2/20 | 0.73 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.73 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.73 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.73 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.73 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.73 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5568872 | 0.97 | KDR (1.00) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017084 | 0.97 | KDR (1.00) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017298 | 0.93 | KDR (0.82) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8808147 | 0.92 | KDR (0.80) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017472 | 0.89 | KDR (0.76) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL22137832 | 0.89 | KDR (0.76) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017482 | 0.89 | KDR (0.75) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017767 | 0.88 | KDR (0.78) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3401165 | 0.88 | NPC1 (0.97) | KDRTEKNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30017359 | 0.86 | KDR (0.71) | KDRTEKNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-8518965-B2 | Compositions and methods for treating cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2012-06-28 | — | — | US | disclosed |
| WO-2011016952-A1 | COMPOSITIONS AND METHODS FOR TREATING CANCER | TRUSTEES OF DARTMOUTH COLLEGE (US) | 2011-02-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165365-A1 | Compositions and Methods for Treating Cancer | MKI67, DCX, NES | KDR 2824/4885TEK 1710/4885NPC1 1376/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.