⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15275663 | 1.00 | — | — | |
| SCHEMBL15275665 | 0.89 | — | — | |
| SCHEMBL10000813 | 0.89 | — | — | |
| SCHEMBL14959974 | 0.84 | — | — | |
| SCHEMBL10000812 | 0.81 | — | — | |
| SCHEMBL10029728 | 0.81 | — | — | |
| SCHEMBL15275664 | 0.81 | — | — | |
| SCHEMBL12507145 | 0.79 | — | — | |
| SCHEMBL10000807 | 0.79 | — | — | |
| SCHEMBL15275662 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8586551-B2 | 18-membered macrocycles and analogs thereof | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-11-19 | — | — | US | disclosed |
| US-20130252913-A1 | 18-Membered Macrocycles and Analogs Thereof | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| US-8445654-B2 | Antibiotic macrocycle compounds and methods of manufacture and use thereof | OPTIMER PHARMACEUTICALS, INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20120040922-A1 | ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MANUFACTURE AND USE THEREOF | MERCK SHARP & DOHME LLC | 2012-02-16 | — | — | US | disclosed |
| US-8044030-B2 | Antibiotic macrocycle compounds and methods of manufacture and use thereof | OPTIMER PHARMACEUTICALS, INC. (US) | 2011-10-25 | — | — | US | disclosed |
| US-20110166090-A1 | 18-Membered Macrocycles and Analogs Thereof | SHUE YOUE-KONG | 2011-07-07 | — | — | US | disclosed |
| US-7906489-B2 | Use of tiacumicin B aka fidaxomicin or OPT-80 to treat diarrhea caused by Clostridium difficile gastrointestinal infection | OPTIMER PHARMACEUTICALS, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100035833-A1 | ANTIBIOTIC MACROCYCLE COMPOUNDS AND METHODS OF MNAUFACTURE AND USE THEREOF | OPTIMER PHARMACEUTICALS, INC. (US) | 2010-02-11 | — | — | US | disclosed |
| US-20100009925-A1 | 18-MEMBERED MACROCYCLES AND ANALOGS THEREOF | MERCK SHARP & DOHME LLC | 2010-01-14 | — | — | US | disclosed |
| US-20080269145-A1 | 18-Membered macrocycles and analogs thereof | MERCK SHARP & DOHME LLC | 2008-10-30 | — | — | US | disclosed |