SCHEMBL10000952

SCHEMBL10000952

CN1C(=O)c2ccc(Oc3ccc(C(C)(C)c4ccc(Oc5ccc6c(c5)C(=O)N(c5ccc(Oc7ccccc7)cc5)C6=O)cc4)cc3)cc2C1=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.55
KMT2A Q03164 6/20 0.51
MEN1 O00255 5/20 0.51
PKM P14618 1/20 0.50
HTT P42858 1/20 0.49
MCHR1 Q99705 1/20 0.48
CA12 O43570 2/20 0.45
CA1 P00915 2/20 0.45
CA9 Q16790 2/20 0.45
ALDH1A1 P00352 2/20 0.45
NPSR1 Q6W5P4 1/20 0.45
POLB P06746 1/20 0.45
MAPK1 P28482 1/20 0.45
PTGES O14684 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
MGLL Q99685 1/20 0.43
MAPT P10636 2/20 0.42
ESR1 P03372 1/20 0.42
LPAR1 Q92633 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12732006 0.96 BRD4 (0.50) BRD4KMT2AMEN1PKMHTT
SCHEMBL84816 0.92 BRD4 (0.58) BRD4KMT2AMEN1PKMHTT
SCHEMBL13238879 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL12432394 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL19220502 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL25464664 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL735210 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL14882399 0.92 MEN1 (0.55) BRD4KMT2AMEN1PKMHTT
SCHEMBL9342244 0.91 BRD4 (0.54) BRD4KMT2AMEN1PKMHTT
SCHEMBL12595837 0.89 BRD4 (0.54) BRD4KMT2AMEN1PKMHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8106147-B2 High strength polyimide membrane and method for forming the same CHUNG YUAN CHRISTIAN UNIVERSITY (TW) 2012-01-31 US disclosed
US-20110137008-A1 HIGH STRENGTH POLYIMIDE MEMBRANE AND METHOD FOR FORMING THE SAME CHUNG YUAN CHRISTIAN UNIVERSITY (TW) 2011-06-09 US disclosed