Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA3 | P42263 | 1/20 | 0.52 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.52 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10001644 | 0.92 | GRIA3 (0.47) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL10001647 | 0.90 | GRIA3 (0.48) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL638015 | 0.81 | GRIA3 (0.57) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL637281 | 0.78 | GRIA3 (0.55) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL10032960 | 0.77 | GRIA3 (0.60) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL637584 | 0.76 | GRIA3 (0.56) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL548676 | 0.74 | GRIA3 (0.59) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL548639 | 0.73 | GRIA3 (0.51) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL548619 | 0.72 | GRIA3 (0.53) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 | |
| SCHEMBL548631 | 0.72 | GRIA3 (0.53) | GRIA3GRIA4EPHX2TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119632-B2 | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses | CORTEX PHARMACEUTICALS, INC. (US) | 2012-02-21 | — | — | US | disclosed |