Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 17/20 | 0.55 |
| ▸ | INCENP | Q9NQS7 | 17/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | STK10 | O94804 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | BCR | P11274 | 1/20 | 0.50 |
| ▸ | FER | P16591 | 1/20 | 0.50 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.50 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | TEC | P42680 | 1/20 | 0.50 |
| ▸ | ABL2 | P42684 | 1/20 | 0.50 |
| ▸ | FRK | P42685 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.50 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.50 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1501008 | 0.93 | AURKA (0.62) | AURKAAURKBINCENPPLK4JAK2 | |
| Trifluoroacetic Acid SCHEMBL10004927 | 0.90 | AURKA (0.66) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501457 | 0.86 | AURKA (0.61) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501131 | 0.84 | AURKA (0.61) | AURKAAURKBINCENPPLK4JAK2 | |
| Trifluoroacetic Acid SCHEMBL1501006 | 0.84 | AURKA (0.77) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL12760570 | 0.82 | AURKA (0.71) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501427 | 0.82 | AURKA (0.62) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501140 | 0.82 | AURKA (0.76) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501136 | 0.82 | AURKA (0.76) | AURKAAURKBINCENPPLK4JAK2 | |
| SCHEMBL1501476 | 0.80 | AURKA (0.76) | AURKAAURKBINCENPPLK4JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2062887-B1 | AMINOPYRIDINE DERIVATIVE HAVING AURORA A-SELECTIVE INHIBITORY ACTIVITY | MSD KK (JP) | 2012-07-04 | — | — | EP | disclosed |