SCHEMBL10012

SCHEMBL10012

CCCCCc1c(C)noc1-c1ccc(Br)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.40
CYP2C19 P33261 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
SIRT2 Q8IXJ6 3/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
NFKB1 P19838 1/20 0.39
MAPK1 P28482 1/20 0.39
NFKB2 Q00653 1/20 0.39
RELA Q04206 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
TP53 P04637 1/20 0.39
MAPT P10636 1/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
EDNRB P24530 4/20 0.36
EDNRA P25101 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27870816 0.84 CYP1A2 (0.42) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL18597812 0.84 CYP1A2 (0.44) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL1652 0.83 CYP1A2 (0.41) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL13482 0.82 LSS (0.35) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL1185 0.81 CYP1A2 (0.44) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL6483 0.80 CYP1A2 (0.43) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL1683 0.80 CYP1A2 (0.43) CYP2C9CYP2C19CYP1A2CYP3A4TDP1
SCHEMBL11994167 0.80 BRD4 (0.43) NPC1RAB9ASMN1; SMN2MAPT
SCHEMBL13967 0.77 PPARG (0.39) CYP2C9CYP2C19CYP1A2L3MBTL1CYP19A1
SCHEMBL5419 0.77 TDP1 (0.41) CYP2C9CYP2C19CYP1A2CYP3A4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2483252-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
EP-2483253-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS Amira Pharmaceuticals, Inc. (US) 2012-08-08 EP disclosed
WO-2011041729-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed
WO-2011041694-A2 COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS AMIRA PHARMACEUTICALS, INC. (US) 2011-04-07 WO disclosed