Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 1/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | SYNJ2 | O15056 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839219 | 0.93 | STING1 (0.43) | STING1ABCB1PTGS1CYP3A4MAPK1 | |
| SCHEMBL26481191 | 0.91 | ABCB1 (0.41) | STING1ABCB1PTGS1CYP3A4MAPK1 | |
| SCHEMBL15450257 | 0.89 | CYP3A4 (0.44) | ABCB1PTGS1CYP3A4MAPK1BACE1 | |
| SCHEMBL15450263 | 0.89 | CYP3A4 (0.44) | ABCB1PTGS1CYP3A4MAPK1BACE1 | |
| SCHEMBL15450266 | 0.89 | CYP3A4 (0.44) | ABCB1PTGS1CYP3A4MAPK1BACE1 | |
| SCHEMBL16016915 | 0.89 | CYP3A4 (0.44) | ABCB1PTGS1CYP3A4MAPK1BACE1 | |
| SCHEMBL24983403 | 0.88 | ABCB1 (0.52) | STING1ABCB1PTGS1CYP3A4MAPK1 | |
| SCHEMBL10016121 | 0.88 | STING1 (0.45) | STING1ABCB1CETP | |
| SCHEMBL513123 | 0.88 | ABCB1 (0.52) | STING1ABCB1PTGS1CYP3A4MAPK1 | |
| SCHEMBL30892442 | 0.88 | ABCB1 (0.52) | STING1ABCB1PTGS1CYP3A4MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9399631-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2016-07-26 | — | — | US | disclosed |
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2014-02-13 | — | — | US | disclosed |
| US-8563607-B2 | Polyphenol proteasome inhibitors, synthesis, and methods of use | UNIVERSITY OF SOUTH FLORIDA (US) | 2013-10-22 | — | — | US | disclosed |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | UNIVERSITY OF SOUTH FLORIDA (US) | 2012-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140045931-A1 | POLYPHENOL PROTEASOME INHIBITORS, SYNTHESIS, AND METHODS OF USE | PSMC1, PSMB5, PSMC5 | STING1 3665/4885ABCB1 2639/4885PTGS1 1774/4885 |
| US-20120029067-A1 | Polyphenol Proteasome Inhibitors, Synthesis, and Methods of Use | PSMC1, PSMB5, PSMC5 | STING1 3665/4885ABCB1 2639/4885PTGS1 1774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.