Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 4/20 | 1.00 |
| ▸ | DYRK3 | O43781 | 3/20 | 1.00 |
| ▸ | ROCK2 | O75116 | 3/20 | 1.00 |
| ▸ | PRKD3 | O94806 | 3/20 | 1.00 |
| ▸ | MAP4K4 | O95819 | 3/20 | 1.00 |
| ▸ | PRKCG | P05129 | 3/20 | 1.00 |
| ▸ | PHKG2 | P15735 | 3/20 | 1.00 |
| ▸ | CDK2 | P24941 | 3/20 | 1.00 |
| ▸ | GSK3A | P49840 | 3/20 | 1.00 |
| ▸ | GSK3B | P49841 | 3/20 | 1.00 |
| ▸ | PRKX | P51817 | 3/20 | 1.00 |
| ▸ | CDK5 | Q00535 | 3/20 | 1.00 |
| ▸ | PRKCD | Q05655 | 3/20 | 1.00 |
| ▸ | STK3 | Q13188 | 3/20 | 1.00 |
| ▸ | PRKG2 | Q13237 | 3/20 | 1.00 |
| ▸ | ROCK1 | Q13464 | 3/20 | 1.00 |
| ▸ | CAMK2B | Q13554 | 3/20 | 1.00 |
| ▸ | CAMK2G | Q13555 | 3/20 | 1.00 |
| ▸ | CAMK2D | Q13557 | 3/20 | 1.00 |
| ▸ | DYRK1A | Q13627 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6849760 | 1.00 | PRKACA (1.00) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6849747 | 1.00 | PRKACA (1.00) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6849753 | 1.00 | PRKACA (1.00) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6849881 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6854515 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6854506 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6849875 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6849880 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL6854511 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 | |
| SCHEMBL30035858 | 0.90 | CHEK1 (0.82) | PRKACADYRK3ROCK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8148089-B2 | Alpha-synuclein kinase | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2012-04-03 | — | — | US | disclosed |
| US-8148089-B2 | Alpha-synuclein kinase | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2012-04-03 | — | — | US | disclosed |
| US-20110207796-A1 | ALPHA-SYNUCLEIN KINASE | ELAN PHARMA INTERNATIONAL LIMITED | 2011-08-25 | — | — | US | disclosed |
| US-20110207796-A1 | ALPHA-SYNUCLEIN KINASE | ELAN PHARMA INTERNATIONAL LIMITED | 2011-08-25 | — | — | US | disclosed |
| US-20100143946-A1 | ALPHA-SYNUCLEIN KINASE | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-06-10 | — | — | US | disclosed |
| US-20100143946-A1 | ALPHA-SYNUCLEIN KINASE | ELAN PHARMA INTERNATIONAL LIMITED (IE) | 2010-06-10 | — | — | US | disclosed |
| US-20080300206-A1 | Alpha-Synuclein Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | US | disclosed |
| US-20080300206-A1 | Alpha-Synuclein Kinase | ELAN PHARMACEUTICALS, INC. (US) | 2008-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110207796-A1 | ALPHA-SYNUCLEIN KINASE | SNCA, PLK2, LMTK2 | PRKACA 140/4885DYRK3 519/4885ROCK2 232/4885 |
| US-20080300206-A1 | Alpha-Synuclein Kinase | SNCA, PLK2, LMTK2 | PRKACA 237/4885DYRK3 339/4885ROCK2 155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.