Sugi Predict

Sugi Predict / Compounds / SCHEMBL10024341

SCHEMBL10024341

SCHEMBL10024341

CC(C)Nc1cc(NC(C)C)cc(NC(C)C)c1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TDP1 Q9NUW8 5/20 0.55
▸ L3MBTL1 Q9Y468 3/20 0.46
▸ ALDH1A1 P00352 3/20 0.46
▸ CYP3A4 P08684 2/20 0.46
▸ THRB P10828 2/20 0.46
▸ ALOX15 P16050 2/20 0.46
▸ TSHR P16473 2/20 0.46
▸ HSD17B10 Q99714 2/20 0.46
▸ RECQL P46063 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ ALOX12 P18054 1/20 0.46
▸ ATM Q13315 1/20 0.46
▸ TRPM8 Q7Z2W7 1/20 0.39
▸ RXFP1 Q9HBX9 1/20 0.37
▸ TRPA1 O75762 2/20 0.36
▸ KCNH3 Q9ULD8 2/20 0.34
▸ TP53 P04637 1/20 0.33
▸ HSP90AA1 P07900 1/20 0.33
▸ CASP1 P29466 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18998887 0.88 TDP1 (0.46) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL20763402 0.88 TDP1 (0.46) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL11404383 0.82 TDP1 (0.46) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL7809681 0.82 TDP1 (0.46) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL9313156 0.82 TDP1 (0.67) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL632093 0.80 TDP1 (0.44) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL11973983 0.80 TDP1 (0.44) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL39430 0.79 TDP1 (0.72) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL20762961 0.78 TDP1 (0.38) TDP1L3MBTL1ALDH1A1CYP3A4THRB
SCHEMBL12810690 0.78 TDP1 (0.42) TDP1L3MBTL1ALDH1A1CYP3A4THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11746126-B2 Bicyclic peptide ligands with detectable moieties and uses thereof Bicyclerd Limited (GB) 2023-09-05 — — US disclosed
US-11746126-B2 Bicyclic peptide ligands with detectable moieties and uses thereof Bicyclerd Limited (GB) 2023-09-05 — — US disclosed
US-20210079045-A1 BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF Bicyclerd Limited (GB) 2021-03-18 — — US disclosed
US-9636643-B2 Polymeric matrices formed from monomers comprising a protected amine group GENERAL ELECTRIC COMPANY (US) 2017-05-02 — — US disclosed
US-20140360932-A1 POLYMERIC MATRICES FORMED FROM MONOMERS COMPRISING A PROTECTED AMINE GROUP BL TECHNOLOGIES, INC. 2014-12-11 — — US disclosed
US-8839960-B2 Polymeric matrices formed from monomers comprising a protected amine group GENERAL ELECTRIC COMPANY (US) 2014-09-23 — — US disclosed
US-20120152822-A1 POLYMERIC MATRICES FORMED FROM MONOMERS COMPRISING A PROTECTED AMINE GROUP BL TECHNOLOGIES, INC. 2012-06-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11746126-B2 Bicyclic peptide ligands with detectable moieties and uses thereof VIP, NGLY1, GRPR TDP1 4302/4885L3MBTL1 1982/4885ALDH1A1 4676/4885
US-20210079045-A1 BICYCLIC PEPTIDE LIGANDS WITH DETECTABLE MOIETIES AND USES THEREOF VIP, NGLY1, GRPR TDP1 4302/4885L3MBTL1 1982/4885ALDH1A1 4676/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.