Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | PARP1 | P09874 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556390 | 0.84 | ENPP1 (0.65) | TSHRENPP1SMN1; SMN2POLBALDH1A1 | |
| SCHEMBL77913 | 0.74 | PARP1 (0.73) | PARP1 | |
| SCHEMBL30416453 | 0.74 | PARP1 (0.73) | PARP1 | |
| SCHEMBL15597471 | 0.74 | MAPT (0.68) | TSHRSMN1; SMN2POLBALDH1A1L3MBTL1 | |
| SCHEMBL24000713 | 0.73 | ENPP1 (0.67) | TSHRENPP1SMN1; SMN2POLBLMNA | |
| SCHEMBL7458097 | 0.72 | SMN1; SMN2 (0.60) | TSHRHPGDSMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL1926951 | 0.71 | FOLH1 (0.66) | CYP2C9 | |
| SCHEMBL70351 | 0.71 | FOLH1 (0.70) | CYP2C9 | |
| SCHEMBL30791058 | 0.71 | FOLH1 (0.70) | CYP2C9 | |
| SCHEMBL12203808 | 0.70 | SMN1; SMN2 (0.61) | TSHRENPP1SMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019427-A1 | PHTHALAZINONE KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |