Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 8/20 | 0.77 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.77 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.77 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.77 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.77 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.77 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.77 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.65 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | HTR1A | P08908 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.57 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.57 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12804583 | 0.92 | HDAC6 (0.77) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL12938910 | 0.91 | HDAC6 (0.73) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL12938922 | 0.88 | HDAC6 (0.78) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL1052951 | 0.87 | HDAC6 (1.00) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL20960968 | 0.87 | HDAC6 (0.77) | HDAC6HDAC1HDAC8HDAC2HDAC3 | |
| SCHEMBL28688118 | 0.86 | — | — | |
| SCHEMBL28669528 | 0.85 | — | — | |
| SCHEMBL6338023 | 0.84 | — | — | |
| SCHEMBL28688326 | 0.83 | — | — | |
| SCHEMBL28689650 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2456757-B1 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | UNIV ILLINOIS (US) | 2019-05-01 | — | — | EP | disclosed |
| US-8748451-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-06-10 | — | — | US | disclosed |
| US-8748451-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2014-06-10 | — | — | US | disclosed |
| US-20130281484-A1 | HDAC Inhibitors and Therapeutic Methods of Using Same | UNIV ILLINOIS (US) | 2013-10-24 | — | — | US | disclosed |
| US-20130281484-A1 | HDAC Inhibitors and Therapeutic Methods of Using Same | UNIV ILLINOIS (US) | 2013-10-24 | — | — | US | disclosed |
| US-8431538-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-04-30 | — | — | US | disclosed |
| US-8431538-B2 | HDAC inhibitors and therapeutic methods of using same | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-04-30 | — | — | US | disclosed |
| US-20120252740-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME | KOZIKOWSKI ALAN (US) | 2012-10-04 | — | — | US | disclosed |
| US-20120252740-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME | KOZIKOWSKI ALAN (US) | 2012-10-04 | — | — | US | disclosed |
| EP-2456757-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | The Board of Trustees of the University of Illinois (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011186-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-01-27 | — | — | WO | disclosed |
| WO-2011011186-A2 | HDAC INHIBITORS AND THERAPEUTIC METHODS USING THE SAME | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252740-A1 | HDAC INHIBITORS AND THERAPEUTIC METHODS OF USING SAME | HDAC1, HDAC9, HDAC5 | HDAC6 7/4885HDAC1 1/4885HDAC8 5/4885 |
| US-20130281484-A1 | HDAC Inhibitors and Therapeutic Methods of Using Same | HDAC1, HDAC9, HDAC5 | HDAC6 7/4885HDAC1 1/4885HDAC8 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.