Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 19/20 | 0.76 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.62 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.62 |
| ▸ | TNKS | O95271 | 2/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.48 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.46 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.46 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.46 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.46 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10039884 | 0.82 | PARP1 (0.56) | PARP1PARP3 | |
| SCHEMBL10039713 | 0.82 | PARP1 (0.52) | PARP1 | |
| SCHEMBL10039881 | 0.81 | PARP1 (0.51) | PARP1 | |
| SCHEMBL10039705 | 0.80 | PARP1 (0.50) | PARP1 | |
| SCHEMBL10039882 | 0.80 | PARP1 (0.55) | PARP1TNKSTNKS2 | |
| SCHEMBL10039889 | 0.79 | PARP1 (0.49) | PARP1PARP3 | |
| SCHEMBL30888475 | 0.77 | PARP1 (1.00) | PARP1PARP3PARP2TNKSTNKS2 | |
| SCHEMBL10025705 | 0.77 | PARP1 (1.00) | PARP1PARP3PARP2TNKSTNKS2 | |
| SCHEMBL10025715 | 0.77 | PARP1 (1.00) | PARP1PARP3PARP2 | |
| SCHEMBL10039883 | 0.77 | PARP1 (0.47) | PARP1TNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019430-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |