Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 20/20 | 0.74 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.49 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29416785 | 0.84 | PARP1 (0.73) | PARP1 | |
| SCHEMBL10025672 | 0.84 | PARP1 (0.73) | PARP1 | |
| SCHEMBL10039736 | 0.81 | PARP1 (0.69) | PARP1 | |
| SCHEMBL10039714 | 0.81 | PARP1 (0.66) | PARP1PARP2PARP3 | |
| SCHEMBL10039767 | 0.81 | PARP1 (0.78) | PARP1PARP2PARP3 | |
| SCHEMBL10039749 | 0.81 | PARP1 (0.68) | PARP1 | |
| SCHEMBL10039888 | 0.80 | PARP1 (0.67) | PARP1PARP3 | |
| SCHEMBL10039712 | 0.79 | PARP1 (0.66) | PARP1 | |
| SCHEMBL10039728 | 0.79 | PARP1 (0.66) | PARP1 | |
| SCHEMBL10039700 | 0.79 | PARP1 (0.75) | PARP1PARP2PARP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019430-A1 | PHTHALAZINONE DERIVATIVE, AND PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |