Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 9/20 | 0.56 |
| ▸ | INSR | P06213 | 5/20 | 0.56 |
| ▸ | EGFR | P00533 | 3/20 | 0.56 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | CDC7 | O00311 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 1/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.56 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.56 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | PAK4 | O96013 | 1/20 | 0.56 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10042755 | 0.85 | ALK (0.59) | ALKINSREGFRPTK2MET | |
| SCHEMBL2127324 | 0.85 | ALK (0.62) | ALKINSREGFRPTK2MET | |
| SCHEMBL10071332 | 0.82 | ALK (0.51) | ALKINSREGFRPTK2MET | |
| SCHEMBL10042776 | 0.82 | ALK (0.51) | ALKINSREGFRPTK2MET | |
| SCHEMBL10042775 | 0.78 | ALK (0.49) | ALKINSREGFRPTK2MET | |
| SCHEMBL10071800 | 0.78 | ALK (0.49) | ALKINSREGFRPTK2MET | |
| SCHEMBL10072052 | 0.77 | ALK (0.51) | ALKINSREGFRPTK2MET | |
| SCHEMBL10042763 | 0.77 | ALK (0.51) | ALKINSREGFRPTK2MET | |
| SCHEMBL9949852 | 0.76 | EGFR (0.73) | ALKINSREGFRPTK2MET | |
| SCHEMBL2127851 | 0.76 | ALK (0.54) | ALKINSREGFRPTK2MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165332-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2012-06-28 | — | — | US | disclosed |
| WO-2010146132-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | CELLZOME LIMITED (GB) | 2010-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165332-A1 | SULFONAMIDES AND SULFAMIDES AS ZAP-70 INHIBITORS | ZAP70, LCK, SYK | ALK 952/4885INSR 2528/4885EGFR 1664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.