Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10044370 | 0.90 | TLR8 (0.73) | TLR8TLR7 | |
| SCHEMBL7515942 | 0.86 | TLR8 (0.55) | TLR8TLR7 | |
| SCHEMBL10044371 | 0.85 | TLR8 (0.61) | TLR8TLR7 | |
| SCHEMBL7505418 | 0.83 | TLR8 (0.60) | TLR8TLR7 | |
| SCHEMBL1095253 | 0.82 | TLR8 (0.52) | TLR8TLR7 | |
| SCHEMBL10044375 | 0.81 | TLR8 (0.47) | TLR8TLR7 | |
| SCHEMBL15625320 | 0.81 | TLR8 (0.64) | TLR8TLR7 | |
| SCHEMBL10044373 | 0.80 | TLR8 (0.53) | TLR8TLR7 | |
| SCHEMBL1806746 | 0.79 | TLR8 (0.75) | TLR8TLR7 | |
| SCHEMBL23789208 | 0.78 | TLR8 (0.61) | TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304407-B2 | 8-substituted benzoazepines as toll-like receptor modulators | ARRAY BIOPHARMA INC. (US) | 2012-11-06 | — | — | US | disclosed |
| US-20120165317-A1 | 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | ARRAY BIOPHARMA INC. (US) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165317-A1 | 8-SUBSTITUTED BENZOAZEPINES AS TOLL-LIKE RECEPTOR MODULATORS | TLR8, TLR7, TLR9 | TLR8 1/4885TLR7 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.