Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ym-543 Free Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC5A2 known ✓ | P31639 | 20/20 | 1.00 |
| ▸ | SLC5A1 | P13866 | 4/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ym-543 Free Acid SCHEMBL980608 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1 | |
| Ym-543 Free Acid SCHEMBL14339156 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1 | |
| Ym-543 Free Acid SCHEMBL17034637 | 1.00 | SLC5A2 (1.00) | SLC5A2SLC5A1 | |
| Ym-543 Free Acid SCHEMBL4239531 | 0.99 | SLC5A2 (0.98) | SLC5A2SLC5A1 | |
| SCHEMBL11910966 | 0.90 | SLC5A2 (0.81) | SLC5A2SLC5A1 | |
| SCHEMBL14536579 | 0.90 | SLC5A2 (0.81) | SLC5A2SLC5A1 | |
| SCHEMBL14590144 | 0.87 | SLC5A2 (0.77) | SLC5A2SLC5A1 | |
| SCHEMBL14590089 | 0.87 | SLC5A2 (0.77) | SLC5A2SLC5A1 | |
| SCHEMBL14590147 | 0.87 | SLC5A2 (0.77) | SLC5A2SLC5A1 | |
| SCHEMBL14590119 | 0.87 | SLC5A2 (1.00) | SLC5A2SLC5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041898-A1 | COMBINATION OF SGLT2 INHIBITOR AND A SUGAR COMPOUND FOR THE TREATMENT OF DIABETES | CELON PHARMA SP. Z O.O. (PL) | 2012-04-05 | — | — | WO | disclosed |