Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | ENTPD5 | O75356 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.31 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10046374 | 1.00 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| SCHEMBL10046373 | 1.00 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| SCHEMBL10046369 | 1.00 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| SCHEMBL10046131 | 1.00 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| Hydrochloric Acid SCHEMBL15193814 | 0.99 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| Hydrochloric Acid SCHEMBL15193849 | 0.99 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| Hydrochloric Acid SCHEMBL15194050 | 0.99 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| Hydrochloric Acid SCHEMBL15194591 | 0.99 | PIK3CB (0.35) | PIK3CBENTPD5CYP19A1PTPN1HIF1A | |
| SCHEMBL15197631 | 0.89 | PIK3CB (0.35) | PIK3CBCYP19A1HSD11B1HSD11B2ABCB1 | |
| SCHEMBL10046135 | 0.89 | ENTPD5 (0.34) | PIK3CBENTPD5PTPN1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2605767-B1 | SHIP1 MODULATORS AND RELATED METHODS | UNIV BRITISH COLUMBIA (CA) | 2016-07-27 | — | — | EP | disclosed |
| EP-2605767-B1 | SHIP1 MODULATORS AND RELATED METHODS | UNIV BRITISH COLUMBIA (CA) | 2016-07-27 | — | — | EP | disclosed |
| US-9000050-B2 | SHIP1 modulators and related methods | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2015-04-07 | — | — | US | disclosed |
| US-9000050-B2 | SHIP1 modulators and related methods | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2015-04-07 | — | — | US | disclosed |
| US-20130217674-A1 | SHIP1 MODULATORS AND RELATED METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2013-08-22 | — | — | US | disclosed |
| US-20130217674-A1 | SHIP1 MODULATORS AND RELATED METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2013-08-22 | — | — | US | disclosed |
| WO-2012024682-A1 | SHIP1 MODULATORS AND RELATED METHODS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2012-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130217674-A1 | SHIP1 MODULATORS AND RELATED METHODS | PPM1D, PPP1R1B, PPM1G | PIK3CB 99/4885ENTPD5 669/4885CYP19A1 4342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.