Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.41 |
| ▸ | SCD | O00767 | 3/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.40 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NSD2 | O96028 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALPI | P09923 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALPG | P10696 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12159791 | 0.86 | HRH3 (0.47) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL1743326 | 0.80 | NPC1 (0.44) | HRH3SCDNPC1RAB9AKDM4E | |
| SCHEMBL13648900 | 0.79 | NPC1 (0.56) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL1744081 | 0.79 | MAPT (0.41) | HRH3SCDNPC1RAB9AKDM4E | |
| SCHEMBL13648901 | 0.79 | TP53 (0.50) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL181094 | 0.79 | CHRM4 (0.44) | HRH3SCDNPC1RAB9AKDM4E | |
| SCHEMBL1742473 | 0.78 | CNR2 (0.44) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL3970563 | 0.78 | NPC1 (0.54) | HRH3NPC1RAB9AKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL181795 | 0.78 | CHRM4 (0.43) | HRH3SCDNPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL181471 | 0.78 | TP53 (0.49) | HRH3NPC1RAB9AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079732-B9 | 3- (1, 3-BENZ0DI0X0L-5-YL) -6- (4-CYCLOPROPYLPIPERAZIN-1-YL) -PYRIDAZINE, ITS SALTS AND SOLVATES AND ITS USE AS HISTAMINE H3 RECEPTOR ANTAGONIST | HIGH POINT PHARMACEUTICALS LLC (US) | 2012-03-21 | — | — | EP | disclosed |
| EP-2079732-B1 | 3- (1, 3-BENZ0DI0X0L-5-YL) -6- (4-CYCLOPROPYLPIPERAZIN-1-YL) -PYRIDAZINE, ITS SALTS AND SOLVATES AND ITS USE AS HISTAMINE H3 RECEPTOR ANTAGONIST | HIGH POINT PHARMACEUTICALS LLC (US) | 2011-12-21 | — | — | EP | disclosed |