Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 19/20 | 0.71 |
| ▸ | FAP | Q12884 | 5/20 | 0.59 |
| ▸ | POU2F2 | P09086 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | POU2F1 | P14859 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | HRH2 | P25021 | 1/20 | 0.59 |
| ▸ | MC4R | P32245 | 1/20 | 0.59 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.59 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.59 |
| ▸ | GHSR | Q92847 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16391894 | 0.92 | DPP4 (0.73) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL14935777 | 0.92 | DPP4 (0.83) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL29576288 | 0.92 | DPP4 (0.83) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL639988 | 0.92 | DPP4 (0.83) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL637493 | 0.92 | DPP4 (0.83) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL16392281 | 0.92 | DPP4 (0.68) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL636708 | 0.92 | DPP4 (0.67) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL6239201 | 0.92 | DPP4 (0.67) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL3969508 | 0.86 | DPP4 (0.80) | DPP4FAPPOU2F2ADORA3CHRM1 | |
| SCHEMBL3972211 | 0.86 | DPP4 (0.80) | DPP4FAPPOU2F2ADORA3CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014059938-A1 | METHOD FOR PREPARING IMPORTANT INTERMEDIATE OF LINAGLIPTIN | 药源药物化学（上海）有限公司 (CN) | 2014-04-24 | — | — | WO | disclosed |
| EP-2468749-A1 | Process for the preparation of Linagliptin | Dipharma Francis S.r.l. (IT) | 2012-06-27 | — | — | EP | disclosed |