⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27353408 | 1.00 | — | — | |
| SCHEMBL17067230 | 1.00 | — | — | |
| SCHEMBL10048524 | 1.00 | — | — | |
| SCHEMBL16889138 | 1.00 | — | — | |
| SCHEMBL13475589 | 1.00 | — | — | |
| SCHEMBL10455299 | 1.00 | — | — | |
| SCHEMBL2627313 | 1.00 | — | — | |
| SCHEMBL40974 | 1.00 | — | — | |
| SCHEMBL2627314 | 1.00 | — | — | |
| SCHEMBL16890226 | 0.94 | CA1 (0.68) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9242984-B2 | Pyrazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2016-01-26 | — | — | US | disclosed |
| US-20150191461-A1 | PYRAZOLYL DERIVATIVES AS SYK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-07-09 | — | — | US | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| WO-2012000598-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |