Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | FADS1 | O60427 | 1/20 | 0.59 |
| ▸ | MAOB | P27338 | 3/20 | 0.55 |
| ▸ | MAOA | P21397 | 2/20 | 0.55 |
| ▸ | KCNQ3 | O43525 | 3/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 3/20 | 0.54 |
| ▸ | KCNE1 | P15382 | 3/20 | 0.54 |
| ▸ | KCNQ1 | P51787 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 5/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.52 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11314857 | 0.85 | NPC1 (0.56) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL19157142 | 0.85 | NPC1 (0.65) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL10947015 | 0.85 | HDAC1 (0.62) | NPC1RAB9AMAOBKCNQ3KCNQ2 | |
| SCHEMBL19070454 | 0.84 | MAPT (0.59) | NPC1RAB9AKCNQ3KCNQ2MEN1 | |
| SCHEMBL17784121 | 0.84 | NPC1 (0.60) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL1924842 | 0.83 | NPC1 (0.60) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL1265375 | 0.82 | MEN1 (0.69) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL2679067 | 0.82 | NPC1 (0.73) | NPC1RAB9AMAOBMAOAKCNQ3 | |
| SCHEMBL7151571 | 0.82 | MEN1 (0.59) | NPC1RAB9AMAOBMEN1KMT2A | |
| SCHEMBL11574601 | 0.82 | NPC1 (0.56) | NPC1RAB9AKCNQ3KCNQ2KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8426446-B2 | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHARM CO. LTD. (CN) | 2013-04-23 | — | — | US | disclosed |
| US-8426446-B2 | Acrylamide derivative and use thereof in manufacture of medicament | BEIJING SHIQIAO BIOPHARM CO. LTD. (CN) | 2013-04-23 | — | — | US | disclosed |
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | BEIJING JIASHILIANBO PHARM SCI & TECH CO. LTD | 2012-05-10 | — | — | US | disclosed |
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | BEIJING JIASHILIANBO PHARM SCI & TECH CO. LTD | 2012-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120116075-A1 | Acrylamide Derivative And Use Thereof In Manufacture Of Medicament | ABL1, ABL2, BCR | NPC1 4708/4885RAB9A 4310/4885FADS1 2989/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.