Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.50 |
| ▸ | F10 | P00742 | 16/20 | 0.48 |
| ▸ | F2 | P00734 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541689 | 0.82 | F10 (0.61) | F10F2 | |
| SCHEMBL2003465 | 0.79 | F10 (0.45) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL1996016 | 0.78 | PDE4A (0.72) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL2003019 | 0.75 | F10 (0.50) | F10F2 | |
| SCHEMBL3885017 | 0.75 | F10 (0.56) | F10F2 | |
| SCHEMBL1995599 | 0.75 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL5303876 | 0.75 | F10 (0.53) | PDE4APDE4BPDE4CPDE4DF10 | |
| SCHEMBL1995326 | 0.74 | F10 (0.72) | F10F2 | |
| SCHEMBL1997211 | 0.74 | F10 (0.49) | F10F2 | |
| SCHEMBL1996465 | 0.74 | F10 (0.59) | PDE4APDE4BPDE4CPDE4DF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2105436-B1 | Lactam-containing compounds and derivatives thereof as factor XA inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2012-02-08 | — | — | EP | disclosed |