Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 3/20 | 0.52 |
| ▸ | TRDMT1 | O14717 | 3/20 | 0.49 |
| ▸ | WDR5 | P61964 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | RBBP5 | Q15291 | 2/20 | 0.47 |
| ▸ | DPY30 | Q9C005 | 2/20 | 0.47 |
| ▸ | ASH2L | Q9UBL3 | 2/20 | 0.47 |
| ▸ | NNMT | P40261 | 6/20 | 0.46 |
| ▸ | PI4KA | P42356 | 1/20 | 0.45 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.45 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.45 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.45 |
| ▸ | GNMT | Q14749 | 1/20 | 0.44 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | SETD2 | Q9BYW2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18609691 | 1.00 | EZH2 (0.52) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL18609688 | 0.93 | EZH2 (0.47) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL15281889 | 0.93 | EZH2 (0.47) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL803942 | 0.92 | EZH2 (0.48) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL14703564 | 0.92 | EZH2 (0.48) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL10062026 | 0.90 | EZH2 (0.47) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL804138 | 0.89 | DOT1L (0.49) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL14703565 | 0.89 | DOT1L (0.49) | EZH2TRDMT1WDR5KMT2ARBBP5 | |
| SCHEMBL23120211 | 0.86 | DOT1L (0.43) | WDR5KMT2ARBBP5DPY30ASH2L | |
| SCHEMBL23120207 | 0.86 | DOT1L (0.43) | WDR5KMT2ARBBP5DPY30ASH2L |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2614369-B1 | METHOD FOR DETERMINING THE SUITABILITY OF INHIBITORS OF HUMAN EZH2 IN TREATMENT | EPIZYME INC (US) | 2016-02-03 | — | — | EP | disclosed |
| WO-2013138361-A1 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2013-09-19 | — | — | WO | disclosed |
| WO-2012034132-A2 | INHIBITORS OF HUMAN EZH2, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-03-15 | — | — | WO | disclosed |