Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.72 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.72 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.72 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.72 |
| ▸ | PGR | P06401 | 3/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | SERPINA6 | P08185 | 3/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | SHBG | P04278 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 4/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.59 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.59 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3649005 | 1.00 | HIF1A (0.72) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL10597597 | 1.00 | HIF1A (0.72) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL10597610 | 1.00 | HIF1A (0.72) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL147438 | 1.00 | HIF1A (0.72) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL141636 | 0.91 | HIF1A (0.73) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL8712243 | 0.91 | HIF1A (0.73) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL27991637 | 0.91 | HIF1A (0.73) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL141635 | 0.91 | HIF1A (0.73) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL10497312 | 0.89 | HIF1A (0.70) | HIF1ANR3C2NR3C1HSD17B10PGR | |
| SCHEMBL10062789 | 0.89 | HIF1A (0.64) | HIF1ANR3C2NR3C1HSD17B10PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012046050-A1 | NOVEL COMBINATIONS | ASTRAZENECA AB (SE) | 2012-04-12 | — | — | WO | disclosed |