Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 17/20 | 0.84 |
| ▸ | TTK | P33981 | 5/20 | 0.83 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.83 |
| ▸ | INCENP | Q9NQS7 | 4/20 | 0.83 |
| ▸ | AURKA | O14965 | 3/20 | 0.83 |
| ▸ | SRC | P12931 | 9/20 | 0.83 |
| ▸ | FLT3 | P36888 | 9/20 | 0.83 |
| ▸ | KIT | P10721 | 8/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10062890 | 0.92 | ITK (1.00) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062891 | 0.91 | TTK (1.00) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062900 | 0.91 | ITK (1.00) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062888 | 0.91 | ITK (1.00) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062892 | 0.90 | ITK (0.84) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062893 | 0.90 | ITK (0.84) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10063203 | 0.89 | ITK (0.83) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062915 | 0.86 | ITK (0.85) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062895 | 0.84 | ITK (0.82) | ITKTTKAURKBINCENPAURKA | |
| SCHEMBL10062901 | 0.83 | TTK (0.75) | ITKTTKAURKBINCENPAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |