Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.55 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 10/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.51 |
| ▸ | PRKACA | P17612 | 4/20 | 0.51 |
| ▸ | GSK3A | P49840 | 4/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.51 |
| ▸ | PRKX | P51817 | 4/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.51 |
| ▸ | PRKCG | P05129 | 2/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | AKT2 | P31751 | 2/20 | 0.51 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.51 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.51 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063251 | 1.00 | TTK (0.55) | TTKAURKBINCENPROCK1ROCK2 | |
| SCHEMBL10063120 | 0.82 | ITK (0.64) | TTKAURKBINCENPCYP3A4GPR142 | |
| SCHEMBL13987009 | 0.82 | GSK3B (0.54) | AURKBROCK1ROCK2PRKACAGSK3A | |
| SCHEMBL10063145 | 0.79 | ITK (0.51) | TTKAURKBINCENPCYP3A4CYP2D6 | |
| SCHEMBL3104229 | 0.79 | ROCK1 (0.59) | ROCK1ROCK2PRKACAGSK3AGSK3B | |
| SCHEMBL3110316 | 0.79 | ROCK1 (0.59) | ROCK1ROCK2PRKACAGSK3AGSK3B | |
| SCHEMBL3102089 | 0.79 | ROCK1 (0.58) | AURKBROCK1ROCK2PRKACAGSK3A | |
| SCHEMBL3109362 | 0.78 | ROCK1 (0.74) | AURKBROCK1ROCK2PRKACAGSK3A | |
| SCHEMBL15116262 | 0.78 | ITK (0.50) | TTKAURKBINCENPCYP3A4CYP2D6 | |
| SCHEMBL10063158 | 0.78 | ITK (0.50) | TTKAURKBINCENPCYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184259-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-20130184259-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-18 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130184259-A1 | PYRIDONES USEFUL AS INHIBITORS OF KINASES | MAP3K20, MAP3K6, MAP3K5 | TTK 242/4885AURKB 167/4885INCENP 1903/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.