Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 11/20 | 0.73 |
| ▸ | TYK2 | P29597 | 4/20 | 0.73 |
| ▸ | JAK2 | O60674 | 9/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL42662 | 0.90 | JAK1 (0.58) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL42533 | 0.85 | JAK1 (0.73) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL45183 | 0.85 | JAK1 (0.59) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL2242721 | 0.85 | JAK1 (1.00) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL42851 | 0.82 | JAK2 (0.64) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL13031259 | 0.81 | JAK1 (0.72) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL45132 | 0.80 | TYK2 (0.61) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL41136 | 0.79 | JAK2 (0.72) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL2237041 | 0.76 | JAK1 (0.77) | JAK1TYK2JAK2JAK3 | |
| SCHEMBL13031172 | 0.75 | JAK2 (1.00) | JAK1TYK2JAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130143915-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2013-06-06 | — | — | US | disclosed |
| US-20130143915-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2013-06-06 | — | — | US | disclosed |
| WO-2012000970-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | CELLZOME LIMITED (GB) | 2012-01-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130143915-A1 | TRIAZOLOPYRIDINES AS TYK2 INHIBITORS | TYK2, IRAK1, IRAK2 | JAK1 6/4885TYK2 1/4885JAK2 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.