Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 8/20 | 0.42 |
| ▸ | RAB9A | P51151 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8365120 | 0.85 | EPHX2 (0.52) | SMN1; SMN2ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL10422627 | 0.85 | EPHX2 (0.52) | SMN1; SMN2ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL10423263 | 0.85 | EPHX2 (0.52) | SMN1; SMN2ALDH1A1MAPTKDM4EKMT2A | |
| SCHEMBL13841169 | 0.84 | TDP1 (0.62) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL17016712 | 0.84 | TDP1 (0.47) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL13039993 | 0.83 | NPC1 (0.47) | SMN1; SMN2ALDH1A1MAPTHTTTDP1 | |
| SCHEMBL27488370 | 0.82 | HTT (0.42) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL3060942 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL11974036 | 0.79 | HTT (0.71) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT | |
| SCHEMBL855399 | 0.79 | TDP1 (0.67) | SMN1; SMN2ALDH1A1MAPTKDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | SUNESIS PHARMACEUTICALS, INC. (US) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077711-A1 | Novel Ligands and Libraries of Ligands | LSS, ABCG2, SELL | SMN1; SMN2 4117/4885ALDH1A1 533/4885MAPT 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.