Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17173181 | 0.82 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2HPGDNPC1 | |
| SCHEMBL10068011 | 0.81 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL18082348 | 0.78 | NR1H2 (0.58) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL16759817 | 0.78 | NR1H2 (0.58) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL31444567 | 0.78 | NR1H2 (0.47) | NR1H2USP2SMN1; SMN2HPGDALDH1A1 | |
| SCHEMBL29215824 | 0.74 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL30241638 | 0.74 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL30241467 | 0.74 | NR1H2 (0.48) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL28854725 | 0.74 | NR1H2 (0.44) | NR1H2USP2SMN1; SMN2GPR119HPGD | |
| SCHEMBL10739134 | 0.74 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2GPR119HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |