Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38987 | 0.87 | MAPT (0.59) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL2809253 | 0.83 | MAPT (0.59) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL1189205 | 0.81 | GPBAR1 (0.41) | MAPTRAB9APOLBGPBAR1LIMK2 | |
| SCHEMBL39386 | 0.81 | MAPT (0.53) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL46505 | 0.80 | MAPT (0.51) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL46506 | 0.80 | MAPT (0.51) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL89205 | 0.79 | MAPT (0.54) | MAPTRAB9AL3MBTL1POLBALDH1A1 | |
| SCHEMBL12733610 | 0.79 | MAPT (0.54) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL89250 | 0.79 | MAPT (0.53) | MAPTRAB9ALMNAATMTDP1 | |
| SCHEMBL16533943 | 0.78 | MAPT (0.53) | MAPTRAB9ALMNAATMTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019428-A1 | BENZOHYDROL DERIVATIVES, A PREPARATION PROCESS AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-02-16 | — | — | WO | disclosed |