Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 5/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.74 |
| ▸ | RAB9A | P51151 | 7/20 | 0.71 |
| ▸ | NPC1 | O15118 | 6/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | CASP3 | P42574 | 1/20 | 0.65 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.65 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.65 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.65 |
| ▸ | KIT | P10721 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.58 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.58 |
| ▸ | RELA | Q04206 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26208469 | 0.90 | GAA (1.00) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL8741770 | 0.86 | MEN1 (0.76) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1096303 | 0.85 | GAA (0.79) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2705354 | 0.85 | GAA (0.79) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL31290952 | 0.85 | GAA (0.79) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4376632 | 0.82 | GAA (0.74) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL16365487 | 0.81 | GAA (0.73) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL1097467 | 0.81 | GAA (0.72) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL30672478 | 0.81 | GAA (0.72) | GAAMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4834856 | 0.81 | GAA (0.72) | GAAMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2012-08-02 | — | — | US | disclosed |
| US-8153792-B2 | Process for the synthesis of 2-aminothiazole compounds as kinase inhibitors | AB SCIENCE (FR) | 2012-04-10 | — | — | US | disclosed |
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | 4SC AG (DE) | 2011-03-17 | — | — | US | disclosed |
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | AB SCIENCE (FR) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065734-A1 | NOVEL BIFUNCTIONAL COMPOUNDS WHICH INHIBIT PROTEIN KINASES AND HISTONE DEACETYLASES | HDAC1, HDAC11, MAP2K2 | GAA 846/4885MEN1 2479/4885KMT2A 318/4885 |
| US-20100121063-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, KIT | GAA 1899/4885MEN1 2544/4885KMT2A 291/4885 |
| US-20120196871-A1 | PROCESS FOR THE SYNTHESIS OF 2-AMINOTHIAZOLE COMPOUNDS AS KINASE INHIBITORS | ABL1, ABL2, ALK | GAA 1823/4885MEN1 2595/4885KMT2A 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.