Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10710091 | 0.83 | TDP1 (0.47) | TDP1ALDH1A1FFAR3CYP2C19TSHR | |
| SCHEMBL13545229 | 0.80 | — | — | |
| SCHEMBL285840 | 0.80 | — | — | |
| SCHEMBL16620465 | 0.79 | TDP1 (0.43) | TDP1ALDH1A1FFAR3CYP2C19TSHR | |
| SCHEMBL29803938 | 0.79 | TDP1 (0.43) | TDP1ALDH1A1FFAR3CYP2C19TSHR | |
| SCHEMBL28331576 | 0.79 | TDP1 (0.43) | TDP1ALDH1A1FFAR3CYP2C19TSHR | |
| SCHEMBL30067122 | 0.78 | TDP1 (0.47) | TDP1ALDH1A1FFAR3CYP2C19CA2 | |
| SCHEMBL16705749 | 0.78 | TDP1 (0.47) | TDP1ALDH1A1FFAR3TSHR | |
| SCHEMBL25543737 | 0.78 | TDP1 (0.47) | TDP1ALDH1A1FFAR3CA2 | |
| SCHEMBL18489555 | 0.78 | TDP1 (0.47) | TDP1ALDH1A1FFAR3CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165228-A1 | EVOLVING NEW MOLECULAR FUNCTION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-06-28 | — | — | US | disclosed |
| US-8206914-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-26 | — | — | US | disclosed |
| US-7998904-B2 | Libraries of oligonucleotides created by genetic engineering | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-08-16 | — | — | US | disclosed |
| US-20110190141-A1 | Evolving New Molecular Function | PRESIDENT AND FELLOWS OF HAVARD COLLEGE (US) | 2011-08-04 | — | — | US | disclosed |
| US-7771935-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-08-10 | — | — | US | disclosed |
| US-7557068-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2009-07-07 | — | — | US | disclosed |
| US-7223545-B2 | Evolving new molecular function | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-05-29 | — | — | US | disclosed |
| CN-1003909-B | Novel liquid extracting agent for extracting phosphoric acid and extracting method thereof | 华中师范大学 | 1989-04-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165228-A1 | EVOLVING NEW MOLECULAR FUNCTION | POLI, PCNA, POLK | TDP1 1507/4885ALDH1A1 4698/4885FFAR3 3901/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.