Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 6/20 | 0.73 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470979 | 1.00 | KCNH2 (0.73) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL13963489 | 1.00 | KCNH2 (0.73) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL4027326 | 0.99 | KCNH2 (0.71) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| Fluoride SCHEMBL4026808 | 0.98 | KCNH2 (0.70) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL4026818 | 0.96 | KCNH2 (0.68) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL13973963 | 0.90 | KCNH2 (0.71) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL13520154 | 0.90 | KCNH2 (0.71) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL13263358 | 0.90 | KCNH2 (0.71) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL23298397 | 0.89 | CYP3A4 (0.72) | KCNH2CYP3A4KDM4EALDH1A1HPGD | |
| SCHEMBL13270264 | 0.88 | KCNH2 (0.90) | KCNH2CYP3A4KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7868021-B2 | Antimicrobial quinolones, their compositions and uses | WARNER CHILCOTT COMPANY, LLC (US) | 2011-01-11 | — | — | US | claimed |
| US-20090111851-A1 | Antimicrobial Quinolones, Their Compositions and Uses | WARNER CHILCOTT COMPANY, LLC | 2009-04-30 | — | — | US | claimed |
| EP-1015445-B1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | PROCTER & GAMBLE (US) | 2009-02-25 | — | — | EP | claimed |
| EP-1015445-B1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | PROCTER & GAMBLE (US) | 2009-02-25 | — | — | EP | disclosed |
| US-7482454-B2 | Antimicrobial quinolones, their compositions, and uses | THE PROCTER & GAMBLE COMPANY (US) | 2009-01-27 | — | — | US | disclosed |
| US-20060100436-A1 | Antimicrobial quinolones, their compositions, and uses | WARNER CHILCOTT COMPANY, LLC | 2006-05-11 | — | — | US | disclosed |
| US-6329391-B1 | ANTIBIOTICS, BACTERICIDES USING QUINOLONES | THE PROCTER & GAMBLE CO. | 2001-12-11 | — | — | US | disclosed |
| EP-1015445-A1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | THE PROCTER & GAMBLE COMPANY (US) | 2000-07-05 | — | — | EP | disclosed |
| WO-1999014214-A1 | ANTIMICROBIAL QUINOLONES, THEIR COMPOSITIONS AND USES | THE PROCTER & GAMBLE COMPANY (US) | 1999-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060100436-A1 | Antimicrobial quinolones, their compositions, and uses | Q6ZSR9, RECQL, QARS1 | KCNH2 1112/4885CYP3A4 185/4885KDM4E 2599/4885 |
| US-20090111851-A1 | Antimicrobial Quinolones, Their Compositions and Uses | QARS1, NQO2, TOP2A | KCNH2 1402/4885CYP3A4 280/4885KDM4E 4074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.