Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 20/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | RARG | P13631 | 1/20 | 0.50 |
| ▸ | RARA | P10276 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd-1656 SCHEMBL20299733 | 0.86 | GCK (1.00) | GCKKCNH2RARG | |
| Azd-1656 SCHEMBL321593 | 0.86 | GCK (1.00) | GCKKCNH2RARG | |
| Azd-1656 SCHEMBL30292634 | 0.86 | GCK (1.00) | GCKKCNH2RARG | |
| Azd-1656 SCHEMBL29358604 | 0.86 | GCK (1.00) | GCKKCNH2RARG | |
| Azd-1656 SCHEMBL1427162 | 0.86 | GCK (1.00) | GCKKCNH2RARG | |
| SCHEMBL2667096 | 0.82 | GCK (0.76) | GCKKCNH2RARGRARARARB | |
| SCHEMBL1042657 | 0.80 | GCK (0.64) | GCKKCNH2RARG | |
| SCHEMBL2660380 | 0.79 | GCK (0.65) | GCKKCNH2RARGRARARARB | |
| SCHEMBL1427153 | 0.79 | GCK (0.65) | GCKKCNH2RARGRARARARB | |
| SCHEMBL2667105 | 0.79 | GCK (0.49) | GCKKCNH2RARGRARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093252-B2 | Crystalline polymorphic form of glucokinase activator | ASTRAZENECA AB (SE) | 2012-01-10 | — | — | US | disclosed |
| US-20100210621-A1 | CRYSTALLINE POLYMORPHIC FORM 631 | ASTRAZENECA AB (SE) | 2010-08-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100210621-A1 | CRYSTALLINE POLYMORPHIC FORM 631 | GCKR, GCK, HK1 | GCK 2/4885KCNH2 631/4885RARG 3132/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.