⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1007253 | 0.92 | LCK (0.61) | — | |
| SCHEMBL1006544 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1006947 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1006814 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1005572 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1008879 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1006839 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1007208 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1008153 | 0.90 | LCK (0.65) | — | |
| SCHEMBL1007485 | 0.90 | LCK (0.65) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107624113-B | Tetrahydropyridopyrimidines and tetrahydropyridopyridines as inhibitors of HBsAg (HBV surface antigen) and HBV DNA production for the treatment of hepatitis B virus infection | 豪夫迈·罗氏有限公司 | 2020-10-23 | — | — | CN | claimed |
| EP-3292120-B1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | HOFFMANN LA ROCHE (CH) | 2019-06-19 | — | — | EP | claimed |
| EP-3292120-A1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | H. Hoffnabb-La Roche Ag (CH) | 2018-03-14 | — | — | EP | claimed |
| US-9845322-B2 | Tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis B virus infection | HOFFMANN-LA ROCHE INC. (US) | 2017-12-19 | — | — | US | claimed |
| WO-2016177655-A1 | TETRAHYDROPYRIDOPYRIMIDINES AND TETRAHYDROPYRIDOPYRIDINES AS INHIBITORS OF HBSAG (HBV SURFACE ANTIGEN) AND HBV DNA PRODUCTION FOR THE TREATMENT OF HEPATITIS B VIRUS INFECTIONS | F. HOFFMANN-LA ROCHE AG (CH) | 2016-11-10 | — | — | WO | claimed |
| US-20160326167-A1 | Novel Tetrahydropyridopyrimidines and Tetrahydropyridopyridines for the Treatment and Prophylaxis of Hepatitis B Virus Infection | HOFFMANN-LA ROCHE INC. (US) | 2016-11-10 | — | — | US | claimed |
| US-6737389-B1 | Method for treating textile | Coöperatie Cosun U.A. (NL) | 2004-05-18 | — | — | US | claimed |
| EP-1084216-B1 | METHOD FOR TREATING TEXTILE | COOPERATIE COSUN U A (NL) | 2003-01-08 | — | — | EP | claimed |
| EP-1084216-A1 | METHOD FOR TREATING TEXTILE | Coöperatie Cosun U.A. (NL) | 2001-03-21 | — | — | EP | claimed |
| WO-1999064551-A1 | METHOD FOR TREATING TEXTILE | Coöperatie Cosun U.A. (NL) | 1999-12-16 | — | — | WO | claimed |
| WO-1998025972-A1 | FRUCTAN-POLYCARBOXYLIC ACID | COOPERATIE COSUN U.A. (NL) | 1998-06-18 | — | — | WO | claimed |
| EP-0044105-B1 | NEW 8-ALPHA-OESTRA-1,3,5(10)-TRIENE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS | AKZO N.V. (NL) | 1984-10-03 | — | — | EP | claimed |
| EP-0044105-A2 | New 8-alpha-oestra-1,3,5(10)-triene derivatives, processes for their preparation and pharmaceutical compositions | AKZO N.V. (NL) | 1982-01-20 | — | — | EP | claimed |
| EP-4219767-A1 | PAPD5 AND PAPD7 INHIBITORS FOR TREATING A HEPATITIS B INFECTION | F. Hoffmann-La Roche AG (CH) | 2023-08-02 | — | — | EP | disclosed |
| CN-109328237-B | Inhibitors of PAPD5 and PAPD7 for the treatment of hepatitis b infection | 豪夫迈·罗氏有限公司 | 2022-12-06 | — | — | CN | disclosed |
| US-20220096527-A1 | PAPD5 AND PAPD7 INHIBITORS FOR TREATING A HEPATITIS B INFECTION | HOFFMANN-LA ROCHE INC. (US) | 2022-03-31 | — | — | US | disclosed |
| WO-1998034603-A1 | USE OF BETULIN AND ANALOGS THEREOF TO TREAT HERPESVIRUS INFECTION | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1998-08-13 | — | — | WO | disclosed |
| EP-0014005-B1 | NOVEL ALKYLATED PREGNANES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | AKZO N.V. (NL) | 1983-08-03 | — | — | EP | disclosed |
| US-4260605-A | ANTIINFLAMMATORY AGENTS, SULFONATION AND SUBSEQUENT ACYLATION OF SUBSTITUTED PREGNANE | AKZO N.V. (NL) | 1981-04-07 | — | — | US | disclosed |
| EP-0014005-A1 | Novel alkylated pregnanes, processes for their preparation and pharmaceutical compositions containing same | AKZO N.V. (NL) | 1980-08-06 | — | — | EP | disclosed |