⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10072846 | 0.85 | — | — | |
| SCHEMBL26290377 | 0.85 | — | — | |
| SCHEMBL12990440 | 0.82 | — | — | |
| SCHEMBL12583005 | 0.82 | — | — | |
| SCHEMBL12583009 | 0.81 | — | — | |
| SCHEMBL12150949 | 0.80 | — | — | |
| SCHEMBL26290375 | 0.80 | — | — | |
| SCHEMBL12583002 | 0.79 | — | — | |
| SCHEMBL12990774 | 0.79 | — | — | |
| SCHEMBL12150948 | 0.76 | CYP2D6 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8648054-B2 | 4′-substituted nucleoside derivatives as inhibitors of HCV RNA replication | ROCHE PALO ALTO LLC (US) | 2014-02-11 | — | — | US | disclosed |
| US-20130237491-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | ROCHE PALO ALTO LLC (US) | 2013-09-12 | — | — | US | disclosed |
| US-20120034184-A1 | 4'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AS INHIBITORS OF HCV RNA REPLICATION | DEVOS RENE ROBERT (GB) | 2012-02-09 | — | — | US | disclosed |