Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.67 |
| ▸ | SYK | P43405 | 2/20 | 0.67 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.67 |
| ▸ | FES | P07332 | 1/20 | 0.67 |
| ▸ | FER | P16591 | 1/20 | 0.67 |
| ▸ | FRK | P42685 | 1/20 | 0.67 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.67 |
| ▸ | PIKFYVE | Q9Y2I7 | 1/20 | 0.67 |
| ▸ | SENP6 | Q9GZR1 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 7/20 | 0.51 |
| ▸ | LMNA | P02545 | 6/20 | 0.51 |
| ▸ | APAF1 | O14727 | 5/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 4/20 | 0.51 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.51 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL425075 | 0.92 | TYK2 (0.79) | TYK2SYKIRAK4FESFER | |
| SCHEMBL425074 | 0.92 | TYK2 (0.79) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13759326 | 0.92 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| SCHEMBL424838 | 0.88 | TYK2 (0.84) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13759120 | 0.88 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13758964 | 0.88 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13758968 | 0.88 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| SCHEMBL13758961 | 0.88 | TYK2 (0.69) | TYK2SYKIRAK4FESFER | |
| SCHEMBL424837 | 0.88 | TYK2 (0.84) | TYK2SYKIRAK4FESFER | |
| SCHEMBL428108 | 0.87 | TYK2 (0.86) | TYK2SYKIRAK4FESFER |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458687-B1 | PYRIMIDINE COMPOUNDS AS INTERLEUKIN-12 (IL-12) INHIBITORS | SYNTA PHARMACEUTICALS CORP (US) | 2012-01-11 | — | — | EP | disclosed |
| WO-2009100406-A2 | TOPICAL FORMULATIONS FOR THE TREATMENT OF PSORIASIS | SYNTA PHARMACEUTICALS CORP. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2007050980-A2 | PROCESS FOR PREPARING MESYLATE SALTS OF IL-12 INHIBITORY COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2007-05-03 | — | — | WO | disclosed |