Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RYR2 | Q92736 | 16/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6867068 | 0.91 | ESR2 (0.46) | ESR2NR1H2MAPK1RYR2HDAC1 | |
| SCHEMBL8196121 | 0.84 | RYR2 (0.39) | ESR2RYR2 | |
| SCHEMBL6867410 | 0.83 | NR1H2 (0.49) | ESR2NR1H2MAPK1RYR2HDAC1 | |
| SCHEMBL6867859 | 0.83 | ESR2 (0.47) | ESR2NR1H2MAPK1RYR2HDAC1 | |
| SCHEMBL13622125 | 0.83 | ESR2 (0.47) | ESR2NR1H2MAPK1RYR2 | |
| SCHEMBL6866566 | 0.80 | ESR2 (0.45) | ESR2NR1H2MAPK1RYR2HDAC1 | |
| SCHEMBL12265359 | 0.80 | RYR2 (0.43) | ESR2NR1H2MAPK1RYR2 | |
| SCHEMBL807127 | 0.78 | ESR2 (0.65) | ESR2NR1H2MAPK1RYR2 | |
| SCHEMBL13622263 | 0.78 | RYR2 (0.46) | ESR2NR1H2MAPK1RYR2HDAC1 | |
| SCHEMBL30015973 | 0.77 | ESR2 (0.51) | ESR2NR1H2MAPK1RYR2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012019071-A1 | METHODS OF PREVENTING AND TREATING SARCOPENIA | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2012-02-09 | — | — | WO | disclosed |