Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | IRAK2 | O43187 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.33 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26112782 | 0.82 | SMN1; SMN2 (0.52) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 | |
| SCHEMBL26112778 | 0.82 | SMN1; SMN2 (0.52) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 | |
| SCHEMBL3168997 | 0.82 | — | — | |
| SCHEMBL10075692 | 0.80 | CYP2D6 (0.40) | HRH3CYP3A4CYP2C9L3MBTL3L3MBTL1 | |
| SCHEMBL10077096 | 0.80 | CYP2D6 (0.36) | HRH3CYP3A4CYP2C9L3MBTL3L3MBTL1 | |
| Ammonia Solution, Strong SCHEMBL4295582 | 0.79 | SMN1; SMN2 (0.50) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 | |
| SCHEMBL12022473 | 0.79 | IRAK4 (0.41) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 | |
| SCHEMBL10077095 | 0.78 | CYP2D6 (0.43) | HRH3CYP3A4CYP2C9L3MBTL3L3MBTL1 | |
| SCHEMBL138980 | 0.76 | SMN1; SMN2 (0.44) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 | |
| SCHEMBL862083 | 0.76 | SMN1; SMN2 (0.44) | IRAK4SMN1; SMN2HRH3CYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656373-B1 | DERIVATIVES OF 2-ACYLAMINO-4-PHENYLTHIAZOLE, PREPARATION METHOD THEREOF AND USE OF SAME AS CHEMOKINEANTAGONISTS | SANOFI SA (FR) | 2012-01-18 | — | — | EP | disclosed |