⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1003449 | 0.79 | — | — | |
| SCHEMBL27628616 | 0.77 | CYP3A4 (0.44) | — | |
| SCHEMBL91997 | 0.75 | — | — | |
| SCHEMBL3214006 | 0.75 | — | — | |
| SCHEMBL31556280 | 0.75 | — | — | |
| Formaldehyde SCHEMBL28827398 | 0.74 | CYP3A4 (0.52) | — | |
| SCHEMBL29351078 | 0.72 | — | — | |
| SCHEMBL394363 | 0.72 | — | — | |
| SCHEMBL10422356 | 0.72 | — | — | |
| SCHEMBL28352 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 102 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8044041-B2 | e.g. 4-Chloro-1-hydroxy-phthalazine-6-carboxylic acid [4-chloro-3'-(2-dimethylamino-ethoxy)-biphenyl-3-yl]-amide; multifunctioning protein kinase inhibitors; anticarcinogenic, antiinflammatory, antidiabetic agent, neurodegenerative diseases | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2011-10-25 | — | — | US | claimed |
| US-7442698-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2008-10-28 | — | — | US | claimed |
| US-20080146547-A1 | PHTHALAZINE DERIVATIVES | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2008-06-19 | — | — | US | claimed |
| EP-1654238-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2006-05-10 | — | — | EP | claimed |
| WO-2005009978-A1 | 2-AMINOPYRIMIDINE AND 2-AMINOPYRIDINE-4-CARBAMATES FOR USE IN THE TREATMENT OF AUTOIMMUNE DISEASES | AMGEN INC. (US) | 2005-02-03 | — | — | WO | claimed |
| US-20050026914-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-02-03 | — | — | US | claimed |
| EP-2900645-A1 | 3-PHENYLISOXAZOLIN DERIVATIVES WITH HERBICIDAL ACTION | Bayer CropScience AG (DE) | 2015-08-05 | — | — | EP | disclosed |
| US-20140275463-A1 | ORGANOSILICON COMPOUND AND PRODUCTION PROCESS FOR THE SAME, AND POLYSILOXANE AND PRODUCTION PROCESS FOR THE SAME | CHISSO PETROCHEMICAL CORPORATION (JP) | 2014-09-18 | — | — | US | disclosed |
| EP-1548020-B1 | SILICON COMPOUND | JNC CORP (JP) | 2014-07-23 | — | — | EP | disclosed |
| US-8741934-B2 | Inhibitors of ion channels | PFIZER LIMITED (GB) | 2014-06-03 | — | — | US | disclosed |
| US-20130072471-A1 | Inhibitors of Ion Channels | MARRON BRIAN EDWARD (US) | 2013-03-21 | — | — | US | disclosed |
| US-8367792-B2 | Polysiloxane compound and method of producing the same | JNC CORPORATION (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8357711-B2 | Heterocyclic sulfonamides as inhibitors of ion channels | PFIZER LIMITED (GB) | 2013-01-22 | — | — | US | disclosed |
| WO-2002083653-A1 | TRIAZINYL ACRYLAMIDE DERIVATIVES AS KINASE INHIBITORS | AMGEN INC. (US) | 2002-10-24 | — | — | WO | disclosed |
| EP-0437186-B1 | Melamine derivatives as stabilizers for chlorine containing polymers | CIBA GEIGY AG (CH) | 1995-12-06 | — | — | EP | disclosed |
| EP-0365483-B1 | Mercaptobenzoic-acid esters used as stabilizers for chlorine-containing polymers | CIBA GEIGY AG (CH) | 1993-12-29 | — | — | EP | disclosed |
| US-5272192-A | Melamine derivatives as stabilizers for chloride-containing polymers | CIBA-GEIGY CORPORATION (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0437186-A1 | Melamine derivatives as stabilizers for chlorine containing polymers | CIBA-GEIGY AG (CH) | 1991-07-17 | — | — | EP | disclosed |
| US-5030671-A | Metal carboxylate and/or phenolate mixture | CIBA-GEIGY CORPORATION (US) | 1991-07-09 | — | — | US | disclosed |
| EP-0365483-A1 | Mercaptobenzoic-acid esters used as stabilizers for chlorine-containing polymers | CIBA-GEIGY AG (CH) | 1990-04-25 | — | — | EP | disclosed |