Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 4/20 | 0.56 |
| ▸ | NPC1 | O15118 | 3/20 | 0.56 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12055335 | 0.85 | MAPT (0.60) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL330358 | 0.83 | MAPT (0.63) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL330103 | 0.81 | BCHE (0.57) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL28730377 | 0.80 | MAPT (0.63) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL29550916 | 0.80 | MAPT (0.63) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL2069803 | 0.78 | BCHE (0.54) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL2069772 | 0.77 | MAPT (0.56) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL10563073 | 0.77 | MAPT (0.66) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL10562259 | 0.76 | MAPT (0.50) | MAPTRAB9ANPC1BCHETP53 | |
| SCHEMBL12325691 | 0.74 | MAPT (0.58) | MAPTRAB9ANPC1BCHETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2407462-A1 | Substituted chroman derivatives, medicaments and use in therapy | Marshall Edwards, Inc. (US) | 2012-01-18 | — | — | EP | disclosed |