Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 11/20 | 1.00 |
| ▸ | LCK | P06239 | 1/20 | 0.84 |
| ▸ | AKT2 | P31751 | 2/20 | 0.68 |
| ▸ | GSK3B | P49841 | 2/20 | 0.68 |
| ▸ | KIT | P10721 | 1/20 | 0.68 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 8/20 | 0.65 |
| ▸ | JAK1 | P23458 | 4/20 | 0.61 |
| ▸ | HTR2C | P28335 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2021330 | 1.00 | JAK3 (1.00) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL20862485 | 0.92 | JAK3 (1.00) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL3954391 | 0.92 | JAK3 (1.00) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL2019457 | 0.92 | LCK (1.00) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL3952874 | 0.86 | JAK3 (0.75) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL20862652 | 0.85 | JAK3 (0.74) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL15178732 | 0.84 | DOT1L (0.85) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL10074309 | 0.84 | DOT1L (0.85) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL15170325 | 0.84 | DOT1L (0.86) | JAK3LCKAKT2GSK3BKIT | |
| SCHEMBL10074310 | 0.84 | DOT1L (0.86) | JAK3LCKAKT2GSK3BKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012022265-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2012-02-23 | — | — | WO | disclosed |