Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERCC5 | P28715 | 2/20 | 0.41 |
| ▸ | FEN1 | P39748 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | RECQL | P46063 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2499880 | 0.84 | EGLN1 (0.58) | KCNH2EGLN1 | |
| SCHEMBL1522475 | 0.74 | KDM4E (0.47) | FEN1SMN1; SMN2LMNATSHRPKM | |
| SCHEMBL1194498 | 0.72 | KDM4E (0.57) | MCL1SMN1; SMN2TSHRPKMALDH1A1 | |
| SCHEMBL1440727 | 0.70 | EGLN1 (0.67) | SMN1; SMN2LMNAALDH1A1RECQLKDM4E | |
| SCHEMBL11422399 | 0.70 | MEN1 (0.47) | SMN1; SMN2LMNATSHRRAB9APKM | |
| SCHEMBL11488105 | 0.69 | CNR1 (0.47) | ERCC5FEN1BCL2MCL1SMN1; SMN2 | |
| SCHEMBL1523169 | 0.69 | KDM4E (0.54) | KCNH2SMN1; SMN2LMNATSHRRAB9A | |
| SCHEMBL1193842 | 0.67 | KDM4E (0.50) | SMN1; SMN2LMNATSHRALDH1A1KDM4E | |
| SCHEMBL16099904 | 0.67 | EGLN1 (0.47) | ERCC5FEN1KDM4EMEN1KMT2A | |
| SCHEMBL115127 | 0.66 | PDE4B (0.38) | SMN1; SMN2LMNATSHRCYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2150251-B1 | THIENOPYRIDINE AND THIAZOLOPYRIDINE DERIVATIVES THAT INHIBIT PROLYL HYDROXYLASE ACTIVITY | AMGEN INC (US) | 2012-06-27 | — | — | EP | disclosed |