Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 17/20 | 0.98 |
| ▸ | FLT3 | P36888 | 14/20 | 0.98 |
| ▸ | SRC | P12931 | 13/20 | 0.98 |
| ▸ | KIT | P10721 | 12/20 | 0.98 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.72 |
| ▸ | JAK2 | O60674 | 1/20 | 0.72 |
| ▸ | LCK | P06239 | 1/20 | 0.72 |
| ▸ | KDR | P35968 | 1/20 | 0.72 |
| ▸ | JAK3 | P52333 | 1/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.65 |
| ▸ | TTK | P33981 | 2/20 | 0.65 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.65 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.65 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10063031 | 0.99 | ITK (1.00) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10063068 | 0.93 | ITK (0.86) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10063102 | 0.93 | ITK (0.85) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL11886734 | 0.93 | ITK (0.85) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL15850173 | 0.90 | ITK (0.81) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL15850153 | 0.89 | ITK (0.79) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10063075 | 0.89 | ITK (0.79) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10063087 | 0.88 | ITK (0.77) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10063052 | 0.87 | ITK (0.79) | ITKFLT3SRCKITMAP3K7 | |
| SCHEMBL10062968 | 0.87 | ITK (1.00) | ITKFLT3SRCKITMAP3K7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831168-B1 | PYRID-2-ONES USEFUL AS INHIBITORS OF TEC FAMILY PROTEIN KINASES FOR THE TREATMENT OF INFLAMMATORY, PROLIFERATIVE AND IMMUNOLOGICALLY-MEDIATED DISEASES. | VERTEX PHARMA (US) | 2014-07-02 | — | — | EP | disclosed |
| US-8101770-B2 | Pyridones useful as inhibitors of kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-01-24 | — | — | US | disclosed |