Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 11/20 | 0.58 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.47 |
| ▸ | PI4KA | P42356 | 2/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.47 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 3/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10081095 | 0.86 | PIK3CG (0.55) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10084741 | 0.85 | PIK3CD (0.56) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10081097 | 0.84 | PIK3CG (0.51) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10081089 | 0.83 | PIK3CG (0.64) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10081159 | 0.83 | PIK3CG (0.64) | PIK3CGPIK3CAABL1MEN1NPC1 | |
| SCHEMBL12342693 | 0.83 | PIK3CG (0.49) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10081098 | 0.82 | PIK3CG (0.58) | PIK3CGPIK3CAPIK3CDABL1NPC1 | |
| SCHEMBL10081096 | 0.81 | PIK3CG (0.57) | PIK3CGPIK3CAPIK3CD | |
| SCHEMBL10081094 | 0.80 | PIK3CG (0.58) | PIK3CGPIK3CAPIK3CDPIK3CBPI4KA | |
| SCHEMBL10081088 | 0.80 | PIK3CG (0.60) | PIK3CGPIK3CAPIK3CDPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8268999-B2 | Tri-cyclic pyrazolopyridine kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-09-18 | — | — | US | disclosed |
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053187-A1 | TRI-CYCLIC PYRAZOLOPYRIDINE KINASE INHIBITORS | PIK3CA, PIK3CD, PIK3CG | PIK3CG 3/4885PIK3CA 1/4885PIK3CD 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.