SCHEMBL1008137

SCHEMBL1008137

CC(C)=CCc1ccc2c(c1)nc(N)c1ncccc12

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 3/20 0.35
HSP90AB1 P08238 2/20 0.35
DHFR P00374 1/20 0.35
TLR7 Q9NYK1 6/20 0.34
PRMT5 O14744 1/20 0.34
GRM2 Q14416 2/20 0.34
MMP14 P50281 1/20 0.33
CCR1 P32246 1/20 0.33
CCR8 P51685 1/20 0.33
IDO1 P14902 1/20 0.33
PSMB5 P28074 1/20 0.33
ALDH1A1 P00352 2/20 0.32
LMNA P02545 2/20 0.32
MAPK1 P28482 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
KDM4E B2RXH2 1/20 0.32
MEN1 O00255 1/20 0.32
USP2 O75604 1/20 0.32
EGFR P00533 1/20 0.32
ERBB2 P04626 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1007451 0.81 KCNH2 (0.40) HSP90AA1HSP90AB1DHFRTLR7PRMT5
SCHEMBL1008775 0.81 HSP90AA1 (0.40) HSP90AA1HSP90AB1DHFRTLR7GRM2
SCHEMBL1007828 0.80 ROCK1 (0.50) HSP90AA1HSP90AB1DHFRTLR7PRMT5
SCHEMBL1007749 0.79 MAP4K4 (0.40) HSP90AA1HSP90AB1DHFRTLR7GRM2
SCHEMBL1006690 0.79 TLR7 (0.42) DHFRTLR7GRM2TLR8
SCHEMBL1006427 0.78 TLR7 (0.43) HSP90AA1HSP90AB1DHFRTLR7PRMT5
SCHEMBL1056691 0.78 NPC1 (0.42) DHFRTLR7PRMT5GRM2SMN1; SMN2
SCHEMBL1008103 0.78 HSP90AA1 (0.37) HSP90AA1HSP90AB1DHFRTLR7PRMT5
SCHEMBL1008350 0.76 KDM4E (0.45) DHFRTLR7KDM4ETLR8
SCHEMBL1063172 0.76 TLR8 (0.49) TLR7TLR8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2268618-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2011-01-05 EP disclosed
WO-2009111337-A1 COMPOUNDS AND COMPOSITIONS AS TLR ACTIVITY MODULATORS IRM LLC (BM) 2009-09-11 WO disclosed