Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1008929 | 0.93 | PDE4D (0.44) | PDE4DKMT2AMEN1ALDH1A1HSP90AA1 | |
| SCHEMBL1008748 | 0.93 | PDE4D (0.45) | PDE4DKMT2AMEN1ALDH1A1CA2 | |
| SCHEMBL1008845 | 0.91 | PDE4D (0.44) | PDE4DKMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL1009113 | 0.90 | PDE4D (0.45) | PDE4D | |
| SCHEMBL1010002 | 0.89 | QPCT (0.49) | PDE4DKMT2AMEN1 | |
| SCHEMBL1009473 | 0.88 | PDE4D (0.42) | PDE4DKMT2AMEN1 | |
| SCHEMBL1010197 | 0.87 | PDE4D (0.44) | PDE4D | |
| SCHEMBL1009086 | 0.86 | PDE4D (0.43) | PDE4DKMT2AMEN1ALDH1A1 | |
| SCHEMBL1011460 | 0.86 | PDE4D (0.54) | PDE4DKMT2AMEN1ALDH1A1CA2 | |
| SCHEMBL1011438 | 0.85 | PDE4D (0.53) | PDE4DKMT2AMEN1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2268632-B1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMA SPA (IT) | 2012-08-08 | — | — | EP | claimed |
| EP-2268632-A1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMACEUTICI S.p.A. (IT) | 2011-01-05 | — | — | EP | claimed |
| US-7820698-B2 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-10-26 | — | — | US | claimed |
| WO-2009127320-A1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-22 | — | — | WO | claimed |
| EP-2110375-A1 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-10-21 | — | — | EP | claimed |
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-15 | — | — | US | claimed |
| EP-2268632-B1 | TERTIARY AMINE DERIVATIVES AS PHOSPHODIESTERASE-4 INHIBITORS | CHIESI FARMA SPA (IT) | 2012-08-08 | — | — | EP | disclosed |
| US-7820698-B2 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.P.A. (IT) | 2010-10-26 | — | — | US | disclosed |
| EP-2110375-A1 | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class | CHIESI FARMACEUTICI S.p.A. (IT) | 2009-10-21 | — | — | EP | disclosed |
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | CHIESI FARMACEUTICI S.P.A. (IT) | 2009-10-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090258905-A1 | PHOSPHODIESTERASE-4 INHIBITORS BELONGING TO THE TERTIARY AMINE CLASS | PDE4A, PDE4B, PDE2A | PDE4D 9/4885KMT2A 1051/4885MEN1 1817/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.