Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA2 | Q9HCG7 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | ANPEP | P15144 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | MMP3 | P08254 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.33 |
| ▸ | PPP5C | P53041 | 1/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10084421 | 1.00 | GBA2 (0.42) | GBA2MMP2ANPEPLMNAPOLB | |
| SCHEMBL31728231 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL20558080 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL10292032 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL3663153 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL10084439 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL10084437 | 0.87 | ATM (0.53) | GBA2MMP2LMNAPOLBSMN1; SMN2 | |
| SCHEMBL13182580 | 0.86 | ANPEP (0.58) | GBA2MMP2ANPEPLMNAPOLB | |
| SCHEMBL8149606 | 0.86 | ANPEP (0.58) | GBA2MMP2ANPEPLMNAPOLB | |
| SCHEMBL1585134 | 0.84 | GBA2 (0.46) | GBA2LMNAPOLBSMN1; SMN2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2468724-A1 | Synthesis of pyrrolidine compounds | Zealand Pharma A/S (DK) | 2012-06-27 | — | — | EP | disclosed |
| WO-2008079266-A2 | SYNTHESIS OF PYRROLIDINE COMPOUNDS | WYETH (US) | 2008-07-03 | — | — | WO | disclosed |