Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 9/20 | 0.59 |
| ▸ | PTGDR | Q13258 | 7/20 | 0.59 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.55 |
| ▸ | PTGFR | P43088 | 1/20 | 0.55 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.55 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.47 |
| ▸ | POLA1 | P09884 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12585567 | 0.90 | NR1H4 (0.57) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL12900500 | 0.89 | PTGER4 (0.47) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL10086325 | 0.89 | PTGER4 (0.49) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL987931 | 0.88 | PTGER4 (0.54) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL12585316 | 0.87 | PTGER4 (0.59) | PTGER4PTGDRPTGER2ALDH1A1NR1H4 | |
| SCHEMBL12585427 | 0.86 | PTGER4 (0.54) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL12948753 | 0.86 | PTGER4 (0.54) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL12585333 | 0.86 | PTGER4 (0.52) | PTGER4PTGDRTBXA2RPTGER1PTGFR | |
| SCHEMBL12585475 | 0.85 | PTGER4 (0.59) | PTGER4PTGDRPTGER2ALDH1A1MMP13 | |
| SCHEMBL12585453 | 0.85 | PTGER4 (0.52) | PTGER4PTGDRALDH1A1NR1H4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2460787-A1 | Amide compounds and their use as PGE2 antagonists. | Astellas Pharma Inc. (JP) | 2012-06-06 | — | — | EP | disclosed |
| US-20110144153-A1 | AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-20110144153-A1 | AMIDE COMPOUND | ASTELLAS PHARMA INC. (JP) | 2011-06-16 | — | — | US | disclosed |
| US-20110028463-A1 | AMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-02-03 | — | — | US | disclosed |
| US-20110028463-A1 | AMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-02-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110144153-A1 | AMIDE COMPOUND | PTGER4, PTGER1, PTGER2 | PTGER4 1/4885PTGDR 13/4885TBXA2R 64/4885 |
| US-20110028463-A1 | AMIDE COMPOUNDS | PTGER4, PTGER1, PTGER2 | PTGER4 1/4885PTGDR 10/4885TBXA2R 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.